Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs
Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules that have emerged as a therapeutic modality to induce targeted protein degradation (TPD) by harnessing cellular proteolytic degradation machinery. PROTACs which ligand the E3 ligase in a covalent manner have attracted intense...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | anglès |
| Publicat: |
2024
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| Accés en línia: | https://doi.org/10.1021/acs.jmedchem.3c02123 https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c02123 |
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