Immune signature of Chlamydia vaccine CTH522/CAF®01 translates from mouse-to-human and induces durable protection in mice

Abstract The clinical development of an effective Chlamydia vaccine requires in-depth understanding of how well protective pre-clinical immune signatures translate to humans. Here, we report a comparative immunological characterization of CTH522/CAF®01 in female mice and humans. We find a range of i...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Anja Weinreich Olsen, Ida Rosenkrands, Christina S. Jacobsen, Hannah M. Cheeseman, Max P Kristiansen, Jes Dietrich, Robin J. Shattock, Frank Follmann
Fformat: Artigo
Iaith:Saesneg
Cyhoeddwyd: 2024
Mynediad Ar-lein:https://doi.org/10.1038/s41467-024-45526-2
https://www.nature.com/articles/s41467-024-45526-2.pdf
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