Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation

Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation

Therapeutic resistance and recurrence remain core challenges in cancer therapy. How therapy resistance arises is currently not fully understood with tumors surviving via multiple alternative routes. Here, we demonstrate that a subset of cancer cells survives therapeutic stress by entering a transien...

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Главные авторы: Christopher Carroll, Auraya Manaprasertsak, Arthur Boffelli Castro, Hilda van den Bos, Diana C.J. Spierings, René Wardenaar, Anuraag Bukkuri, Niklas Engström, Etienne Baratchart, Minjun Yang, Andrea Biloglav, Charlie K. Cornwallis, Bertil Johansson, Catharina Hagerling, Marie Arsenian‐Henriksson, Kajsa Paulsson, Sarah R. Amend, Sofie Mohlin, Floris Foijer, Alan McIntyre, Kenneth J. Pienta, Emma U. Hammarlund
Формат: Artigo
Язык:английский
Опубликовано: 2024
Online-ссылка:https://doi.org/10.1158/2767-9764.crc-23-0396
https://aacrjournals.org/cancerrescommun/article-pdf/4/3/691/3422103/crc-23-0396.pdf
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https://doi.org/10.1158/2767-9764.crc-23-0396
https://aacrjournals.org/cancerrescommun/article-pdf/4/3/691/3422103/crc-23-0396.pdf

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