Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition

Phenoxytacrine derivatives: Low-toxicity neuroprotectants exerting affinity to ifenprodil-binding site and cholinesterase inhibition

Tacrine (THA), a long withdrawn drug, is still a popular scaffold used in medicinal chemistry, mainly for its good reactivity and multi-targeted effect. However, THA-associated hepatotoxicity is still an issue and must be considered in drug discovery based on the THA scaffold. Following our previous...

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Hauptverfasser: Anna Misiachna, Barbora Svobodová, Jakub Netolický, Markéta Chvojková, Lenka Kletečková, Lukáš Prchal, Martin Novák, Martina Hrabinová, Tomáš Kučera, Ľubica Múčková, Zuzana Moravcová, Jana Žďárová Karasová, Jaroslav Pejchal, Filip Blazek, David Maliňák, Kristina Hakenova, Barbora Hrčka Krausová, Marharyta Kolcheva, Marek Ladislav, Jan Korábečný, Jens Pahnke, Karel Valeš, Martin Hořák, Ondřej Soukup
Format: Artigo
Sprache:Englisch
Veröffentlicht: 2024
Online-Zugang:https://doi.org/10.1016/j.ejmech.2024.116130
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https://doi.org/10.1016/j.ejmech.2024.116130

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