A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma

A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma

To better understand intrinsic resistance to immune checkpoint blockade (ICB), we established a comprehensive view of the cellular architecture of the treatment-naive melanoma ecosystem and studied its evolution under ICB. Using single-cell, spatial multi-omics, we showed that the tumor microenviron...

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Hauptverfasser: Joanna Poźniak, Dennis Pedri, Ewout Landeloos, Yannick Van Herck, Asier Antoranz, Lukas Vanwynsberghe, Ada Nowosad, Niccolò Roda, Samira Makhzami, Greet Bervoets, Lucas F. Maciel, Carlos Ariel Pulido-Vicuña, Lotte Pollaris, Ruth Seurinck, Fang Zhao, Karine Flem‐Karlsen, William Damsky, Limin Chen, Despoina Karagianni, Sonia Cinque, Sam Kint, Katy Vandereyken, Benjamin Rombaut, Thierry Voet, Frank Vernaillen, Wim Annaert, Diether Lambrechts, Veerle Boecxstaens, Yvan Saeys, Joost van den Oord, Francesca M. Bosisio, Panagiotis Karras, A. Hunter Shain, Marcus Bosenberg, Eleonora Leucci, Annette Paschen, Florian Rambow, Oliver Bechter, Jean‐Christophe Marine
Format: Artigo
Sprache:Englisch
Veröffentlicht: 2024
Online-Zugang:https://doi.org/10.1016/j.cell.2023.11.037
https://www.cell.com/article/S0092867423013223/pdf
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https://doi.org/10.1016/j.cell.2023.11.037
https://www.cell.com/article/S0092867423013223/pdf

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