Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system

Drug-resistant Mycobacterium tuberculosis (Mtb) remains a major public health concern requiring complementary approaches to standard anti-tuberculous regimens. Anti-virulence molecules or compounds that enhance the activity of antimicrobial prodrugs are promising alternatives to conventional antibio...

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Auteurs principaux: Raphael Gries, Jason Chhen, Edeltraud van Gumpel, Sebastian J. Theobald, Lindsay Sonnenkalb, Christian Utpatel, Fabian Metzen, Manuel Koch, Tobias Dallenga, Kamel Djaout, Alain R. Baulard, Michael Dal Molin, Jan Rybniker
Format: Artigo
Langue:anglais
Publié: 2024
Accès en ligne:https://doi.org/10.1016/j.chembiol.2023.12.007
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