Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy

Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy

Background The metabolism of tryptophan to kynurenines (KYN) by indoleamine-2,3-dioxygenase or tryptophan-2,3-dioxygenase is a key pathway of constitutive and adaptive tumor immune resistance. The immunosuppressive effects of KYN in the tumor microenvironment are predominantly mediated by the aryl h...

Повний опис

Збережено в:
Бібліографічні деталі
Автори: Christina Kober, Julian Roewe, Norbert Schmees, Lars Roese, Ulrike Roehn, Benjamin Bader, Detlef Stoeckigt, Florian Prinz, Mátyás Gorjánácz, Helge G. Roider, Catherine Olesch, Gabriele Leder, Horst Irlbacher, Ralf Lesche, Julien Lefranc, Mine Oezcan-Wahlbrink, Ankita Sati Batra, Nirmeen Elmadany, Rafael Carretero, Katharina Sahm, Iris Oezen, Frederik Cichon, Daniel Baumann, Ahmed Sadik, Christiane A. Opitz, Hilmar Weinmann, Ingo V. Hartung, Bertolt Kreft, Rienk Offringa, Michael Platten, Ilona Gutcher
Формат: Artigo
Мова:Англійська
Опубліковано: 2023
Онлайн доступ:https://doi.org/10.1136/jitc-2023-007495
https://jitc.bmj.com/content/jitc/11/11/e007495.full.pdf
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Інтернет

https://doi.org/10.1136/jitc-2023-007495
https://jitc.bmj.com/content/jitc/11/11/e007495.full.pdf

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