Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury

Abstract Following peripheral nerve injury, successful axonal growth and functional recovery require Schwann cell (SC) reprogramming into a reparative phenotype, a process dependent upon c‐Jun transcription factor activation. Unfortunately, axonal regeneration is greatly impaired in aged organisms a...

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Hlavní autoři: Andrés Flores, Cristian Gerónimo‐Olvera, Karina do Carmo de Vasconcelos Girardi, David Ñecuñir, Sandip Kumar Patel, Joanna Bons, Megan C. Wright, Daniel H. Geschwind, Ahmet Höke, Jose A. Gomez‐Sanchez, Birgit Schilling, Daniela L. Rebolledo, Judith Campisi, Felipe A. Court
Médium: Artigo
Jazyk:angličtina
Vydáno: 2023
On-line přístup:https://doi.org/10.15252/emmm.202317907
https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/emmm.202317907
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https://doi.org/10.15252/emmm.202317907
https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/emmm.202317907

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