Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2
Abstract The Src homology 2 (SH2) domain recognizes phosphotyrosine (pY) post translational modifications in partner proteins to trigger downstream signaling. Drug discovery efforts targeting the SH2 domains have long been stymied by the poor drug-like properties of phosphate and its mimetics. Here,...
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| Hauptverfasser: | , , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Englisch |
| Veröffentlicht: |
2023
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| Online-Zugang: | https://doi.org/10.1038/s41467-023-41894-3 https://www.nature.com/articles/s41467-023-41894-3.pdf |
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