A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo

A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo

Acute myeloid leukemia (AML), the most frequent leukemia in adults, is driven by recurrent somatically acquired genetic lesions in a restricted number of genes. Treatment with tyrosine kinase inhibitors has demonstrated that targeting of prevalent FMS-related receptor tyrosine kinase 3 (FLT3) gain-o...

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Auteurs principaux: Eirini Giannakopoulou, Madeleine Lehander, Stina Virding Culleton, Weiwen Yang, Yingqian Li, Terhi Kärpänen, Tetsuichi Yoshizato, Even H Rustad, Morten M. Nielsen, Ravi Chand Bollineni, Trung Tran, Marina Delić-Šarac, Thea Johanne Gjerdingen, Karolos Douvlataniotis, Maarja Laos, Muhammad Ali, Amy Hillen, Stefania Mazzi, Desmond Wai Loon Chin, Adi Mehta, Jeppe Sejerø Holm, Amalie Kai Bentzen, Marie Bill, Marieke Griffioen, Tobias Gedde‐Dahl, Sören Lehmann, Sten Eirik W. Jacobsen, Petter Woll, Johanna Olweus
Format: Artigo
Langue:anglais
Publié: 2023
Accès en ligne:https://doi.org/10.1038/s43018-023-00642-8
https://www.nature.com/articles/s43018-023-00642-8.pdf
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Internet

https://doi.org/10.1038/s43018-023-00642-8
https://www.nature.com/articles/s43018-023-00642-8.pdf

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