An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status

An active HIV reservoir during ART is associated with maintenance of HIV-specific CD8+ T cell magnitude and short-lived differentiation status

Before initiation of antiretroviral therapy (ART), HIV-specific CD8+ T cells are dysfunctional and short lived. To better understand the relationship between the HIV reservoir in CD4+ T cells and the magnitude and differentiation status of HIV-specific CD8+ T cells, we investigated these cells from...

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Hauptverfasser: Hiroshi Takata, Julie L. Mitchell, Julián Avila Pacheco, Amélie Pagliuzza, Suteeraporn Pinyakorn, Supranee Buranapraditkun, Carlo Sacdalan, Louise Leyre, Sam Nathanson, Juyeon C. Kakazu, Jintana Intasan, Peeriya Prueksakaew, Nitiya Chomchey, Nittaya Phanuphak, Mark de Souza, Elias K. Haddad, Morgane Rolland, Sodsai Tovanabutra, Sandhya Vasan, Denise C. Hsu, Nicolas Chomont, Lydie Trautmann
Format: Artigo
Sprache:Englisch
Veröffentlicht: 2023
Online-Zugang:https://doi.org/10.1016/j.chom.2023.08.012
https://www.cell.com/article/S1931312823003372/pdf
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https://doi.org/10.1016/j.chom.2023.08.012
https://www.cell.com/article/S1931312823003372/pdf

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