Mammalian mitochondrial translation infidelity leads to oxidative stress–induced cell cycle arrest and cardiomyopathy

Mammalian mitochondrial translation infidelity leads to oxidative stress–induced cell cycle arrest and cardiomyopathy

Proofreading (editing) of mischarged tRNAs by cytoplasmic aminoacyl-tRNA synthetases (aaRSs), whose impairment causes neurodegeneration and cardiac diseases, is of high significance for protein homeostasis. However, whether mitochondrial translation needs fidelity and the significance of editing by...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Wen-Qiang Zheng, Jianhui Zhang, Zi-Han Li, Xiuxiu Liu, Yong Zhang, Shuo Huang, Jinsong Li, Bin Zhou, Gilbert Eriani, En‐Duo Wang, Xiao-Long Zhou
Hōputu: Artigo
Reo:Ingarihi
I whakaputaina: 2023
Urunga tuihono:https://doi.org/10.1073/pnas.2309714120
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Ipurangi

https://doi.org/10.1073/pnas.2309714120

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