Mammalian mitochondrial translation infidelity leads to oxidative stress–induced cell cycle arrest and cardiomyopathy

Mammalian mitochondrial translation infidelity leads to oxidative stress–induced cell cycle arrest and cardiomyopathy

Proofreading (editing) of mischarged tRNAs by cytoplasmic aminoacyl-tRNA synthetases (aaRSs), whose impairment causes neurodegeneration and cardiac diseases, is of high significance for protein homeostasis. However, whether mitochondrial translation needs fidelity and the significance of editing by...

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Hlavní autoři: Wen-Qiang Zheng, Jianhui Zhang, Zi-Han Li, Xiuxiu Liu, Yong Zhang, Shuo Huang, Jinsong Li, Bin Zhou, Gilbert Eriani, En‐Duo Wang, Xiao-Long Zhou
Médium: Artigo
Jazyk:angličtina
Vydáno: 2023
On-line přístup:https://doi.org/10.1073/pnas.2309714120
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https://doi.org/10.1073/pnas.2309714120

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