Unrepaired base excision repair intermediates in template <scp>DNA</scp> strands trigger replication fork collapse and <scp>PARP</scp> inhibitor sensitivity

Unrepaired base excision repair intermediates in template <scp>DNA</scp> strands trigger replication fork collapse and <scp>PARP</scp> inhibitor sensitivity

Abstract DNA single‐strand breaks (SSBs) disrupt DNA replication and induce chromosome breakage. However, whether SSBs induce chromosome breakage when present behind replication forks or ahead of replication forks is unclear. To address this question, we exploited an exquisite sensitivity of SSB rep...

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Main Authors: Almudena Serrano-Benítez, Sophie E. Wells, Lylah Drummond‐Clarke, Lilian C. Russo, John C. Thomas, Giovanna A Leal, Mark A. Farrow, James Michael Edgerton, Shankar Balasubramanian, Ming Yang, Christian Frezza, Amit Gautam, Jan Bražina, Kamila Burdová, Nícolas C. Hoch, Stephen P. Jackson, Keith W. Caldecott
Format: Artigo
Jezik:angleščina
Izdano: 2023
Online dostop:https://doi.org/10.15252/embj.2022113190
https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2022113190
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Internet

https://doi.org/10.15252/embj.2022113190
https://onlinelibrary.wiley.com/doi/pdfdirect/10.15252/embj.2022113190

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