Regulatory sites in the Mon1–Ccz1 complex control Rab5 to Rab7 transition and endosome maturation
Maturation from early to late endosomes depends on the exchange of their marker proteins Rab5 to Rab7. This requires Rab7 activation by its specific guanine nucleotide exchange factor (GEF) Mon1–Ccz1. Efficient GEF activity of this complex on membranes depends on Rab5, thus driving Rab–GTPase exchan...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2023
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| Online Access: | https://doi.org/10.1073/pnas.2303750120 |
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