Apilimod activates the NLRP3 inflammasome through lysosome-mediated mitochondrial damage
NLRP3 is an important innate immune sensor that responses to various signals and forms the inflammasome complex, leading to IL-1β secretion and pyroptosis. Lysosomal damage has been implicated in NLRP3 inflammasome activation in response to crystals or particulates, but the mechanism remains unclear...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | anglais |
| Publié: |
2023
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| Accès en ligne: | https://doi.org/10.3389/fimmu.2023.1128700 https://www.frontiersin.org/articles/10.3389/fimmu.2023.1128700/pdf |
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