Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum

Abstract In vitro evolution of drug resistance is a powerful approach for identifying antimalarial targets, however, key obstacles to eliciting resistance are the parasite inoculum size and mutation rate. Here we sought to increase parasite genetic diversity to potentiate resistance selections by ed...

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Main Authors: Krittikorn Kümpornsin, Theerarat Kochakarn, Tomas Yeo, John Okombo, Madeline R. Luth, Johanna Hoshizaki, Mukul Rawat, Richard D. Pearson, Kyra A. Schindler, Sachel Mok, Heekuk Park, Anne‐Catrin Uhlemann, Gouranga P. Jana, Bikash C. Maity, Benoı̂t Laleu, Elodie Chenu, James Duffy, Sonia Moliner Cubel, Virginia Franco, Marı́a G. Gómez-Lorenzo, Francisco‐Javier Gamo, Elizabeth A. Winzeler, David A. Fidock, Thanat Chookajorn, Lee M
Format: Artigo
Jezik:angleščina
Izdano: 2023
Online dostop:https://doi.org/10.1038/s41467-023-38774-1
https://www.nature.com/articles/s41467-023-38774-1.pdf
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https://doi.org/10.1038/s41467-023-38774-1
https://www.nature.com/articles/s41467-023-38774-1.pdf

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