Pictolysin-III, a Hemorrhagic Type-III Metalloproteinase Isolated from Bothrops pictus (Serpentes: Viperidae) Venom, Reduces Mitochondrial Respiration and Induces Cytokine Secretion in Epithelial and Stromal Cell Lines

Pictolysin-III, a Hemorrhagic Type-III Metalloproteinase Isolated from Bothrops pictus (Serpentes: Viperidae) Venom, Reduces Mitochondrial Respiration and Induces Cytokine Secretion in Epithelial and Stromal Cell Lines

From the venom of the Bothrops pictus snake, an endemic species from Peru, we recently have described toxins that inhibited platelet aggregation and cancer cell migration. In this work, we characterize a novel P-III class snake venom metalloproteinase, called pictolysin-III (Pic-III). It is a 62 kDa...

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Auteurs principaux: Dan E. Vivas-Ruiz, Paola C. Rosas, Álex Proleón, Daniel Torrejón, Fanny Lazo, Ana Belén Tenorio-Ricca, Francisco Guajardo, Cristopher Almarza, Víctor Andrades, Jessica Astorga, Daniel Oropesa, Jorge Toledo, María Jesús Vera, Jorge Martı́nez, Ramiro Araya‐Maturana, Karen Dubois-Camacho, Marcela A. Hermoso, Valéria Gonçalves de Alvarenga, Eladio F. Sánchez, Armando Yarlequé, Luciana Souza de Oliveira, Félix A. Urra
Format: Artigo
Langue:anglais
Publié: 2023
Accès en ligne:https://doi.org/10.3390/pharmaceutics15051533
https://www.mdpi.com/1999-4923/15/5/1533/pdf?version=1685080094
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https://doi.org/10.3390/pharmaceutics15051533
https://www.mdpi.com/1999-4923/15/5/1533/pdf?version=1685080094

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