Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1

Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1

Abstract Malaria parasites break down host haemoglobin into peptides and amino acids in the digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is central to the mode of action of several antimalarial drugs. Mutations in the chloroquine (CQ) resistance transp...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Alfred Amambua‐Ngwa, Katrina A. Button-Simons, Xue Li, Sudhir Kumar, Katelyn M. Vendrely, Marco Ferrari, Lisa A. Checkley, Meseret T. Haile, Douglas A. Shoue, Marina McDew‐White, Sarah M. Tindall, Ann Reyes, Elizabeth Delgado, Haley Dalhoff, James K. Larbalestier, Roberto Amato, Richard D. Pearson, A.B. Taylor, François Nosten, Umberto D’Alessandro, Dominic Kwiatkowski, Ian H. Cheeseman, Stefan H. I. Kappe, Simon V. Avery, David J. Conway, Ashley M. Vaughan, Michael T. Ferdig, Timothy J. C. Anderson
Fformat: Artigo
Iaith:Saesneg
Cyhoeddwyd: 2023
Mynediad Ar-lein:https://doi.org/10.1038/s41564-023-01377-z
https://www.nature.com/articles/s41564-023-01377-z.pdf
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https://doi.org/10.1038/s41564-023-01377-z
https://www.nature.com/articles/s41564-023-01377-z.pdf

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