Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis

Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis

Abstract Both fatty bone marrow (FBM) and somatic mutations in hematopoietic stem cells (HSCs), also termed clonal hematopoiesis (CH) accumulate with human aging. However it remains unclear whether FBM can modify the evolution of CH. To address this question, we herein present the interaction betwee...

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Autori principali: Naama Zioni, A. Akhiad Bercovich, Noa Chapal-Ilani, Tal Bacharach, Nadav Rappoport, Adam Solomon, Roi Avraham, Ekaterina Kopitman, Ziv Porat, Mehmet Saçma, G. Hartmut, Marina Scheller, Carsten Müller‐Tidow, Daniel B. Lipka, Ekaterina Shlush, Mark D. Minden, Nathali Kaushansky, Liran I. Shlush
Natura: Artigo
Lingua:inglese
Pubblicazione: 2023
Accesso online:https://doi.org/10.1038/s41467-023-36906-1
https://www.nature.com/articles/s41467-023-36906-1.pdf
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https://doi.org/10.1038/s41467-023-36906-1
https://www.nature.com/articles/s41467-023-36906-1.pdf

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