Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains

Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains

Abstract The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited Alzheimer’s disease. Here, we report the high-resolution cryo-EM structures of Aβ filaments from the frontal cortex of a previously described case ( A β PPar...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Yang Yang, Wenjuan Zhang, Alexey G. Murzin, Manuel Schweighauser, Melissa Huang, Sofia Lövestam, Sew‐Yeu Peak‐Chew, Takashi Saito, Takaomi C. Saido, Jennifer A. Macdonald, Isabelle Lavenir, Bernardino Ghetti, Caroline Graff, Amit Kumar, Agneta Nordberg, Michel Goedert, Sjors H. W. Scheres
Hōputu: Artigo
Reo:Ingarihi
I whakaputaina: 2023
Urunga tuihono:https://doi.org/10.1007/s00401-022-02533-1
https://link.springer.com/content/pdf/10.1007/s00401-022-02533-1.pdf
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Ipurangi

https://doi.org/10.1007/s00401-022-02533-1
https://link.springer.com/content/pdf/10.1007/s00401-022-02533-1.pdf

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