Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains

Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains

Abstract The Arctic mutation, encoding E693G in the amyloid precursor protein (APP) gene [E22G in amyloid-β (Aβ)], causes dominantly inherited Alzheimer’s disease. Here, we report the high-resolution cryo-EM structures of Aβ filaments from the frontal cortex of a previously described case ( A β PPar...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yang Yang, Wenjuan Zhang, Alexey G. Murzin, Manuel Schweighauser, Melissa Huang, Sofia Lövestam, Sew‐Yeu Peak‐Chew, Takashi Saito, Takaomi C. Saido, Jennifer A. Macdonald, Isabelle Lavenir, Bernardino Ghetti, Caroline Graff, Amit Kumar, Agneta Nordberg, Michel Goedert, Sjors H. W. Scheres
Fformat: Artigo
Iaith:Saesneg
Cyhoeddwyd: 2023
Mynediad Ar-lein:https://doi.org/10.1007/s00401-022-02533-1
https://link.springer.com/content/pdf/10.1007/s00401-022-02533-1.pdf
Tagiau: Ychwanegu Tag
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https://doi.org/10.1007/s00401-022-02533-1
https://link.springer.com/content/pdf/10.1007/s00401-022-02533-1.pdf

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