Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells

Unique roles of co-receptor-bound LCK in helper and cytotoxic T cells

Abstract The kinase LCK and CD4/CD8 co-receptors are crucial components of the T cell antigen receptor (TCR) signaling machinery, leading to key T cell fate decisions. Despite decades of research, the roles of CD4–LCK and CD8–LCK interactions in TCR triggering in vivo remain unknown. In this study,...

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Main Authors: Veronika Horková, Ales Drobek, Darina Paprčková, Veronika Niederlová, Avishek Prasai, Valeria Uleri, Daniela Glatzová, Markus Kraller, Michaela Cesnekova, Sarka Janusova, Eva Šályová, Oksana Tsyklauri, Theresa A. Kadlecek, Kateřina Křížová, René Platzer, Kilian Schober, Dirk H. Busch, Arthur Weiss, Johannes B. Huppa, Ondřej Štěpánek
Format: Artigo
Language:English
Published: 2022
Online Access:https://doi.org/10.1038/s41590-022-01366-0
https://www.nature.com/articles/s41590-022-01366-0.pdf
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https://doi.org/10.1038/s41590-022-01366-0
https://www.nature.com/articles/s41590-022-01366-0.pdf

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