Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity
Histone deacetylase 6 (HDAC6) is an attractive drug development target because of its role in the immune response, neuropathy, and cancer. Knockout mice develop normally and have no apparent phenotype, suggesting that selective inhibitors should have an excellent therapeutic window. Unfortunately, c...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2022
|
| 在線閱讀: | https://doi.org/10.1016/j.jbc.2022.102800 http://www.jbc.org/article/S0021925822012431/pdf |
| 標簽: |
添加標簽
沒有標簽, 成為第一個標記此記錄!
|