Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity

Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity

Histone deacetylase 6 (HDAC6) is an attractive drug development target because of its role in the immune response, neuropathy, and cancer. Knockout mice develop normally and have no apparent phenotype, suggesting that selective inhibitors should have an excellent therapeutic window. Unfortunately, c...

Full description

Saved in:
Bibliographic Details
Main Authors: Edoardo Cellupica, Gianluca Caprini, Paola Cordella, C.D. Cukier, Gianluca Fossati, Mattia Marchini, Ilaria Rocchio, Giovanni Sandrone, Maria A. Vanoni, Barbara Vergani, Karol Źrubek, Andrea Stevenazzi, Christian Steinkühler
Format: Artigo
Language:English
Published: 2022
Online Access:https://doi.org/10.1016/j.jbc.2022.102800
http://www.jbc.org/article/S0021925822012431/pdf
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1016/j.jbc.2022.102800
http://www.jbc.org/article/S0021925822012431/pdf

Similar Items