Generation and multiomic profiling of a<i>TP53/CDKN2A</i>double-knockout gastroesophageal junction organoid model

Generation and multiomic profiling of a<i>TP53/CDKN2A</i>double-knockout gastroesophageal junction organoid model

Inactivation of the tumor suppressor genes tumor protein p53 ( TP53 ) and cyclin-dependent kinase inhibitor 2A ( CDKN2A ) occurs early during gastroesophageal junction (GEJ) tumorigenesis. However, because of a paucity of GEJ-specific disease models, cancer-promoting consequences of TP53 and CDKN2A...

Whakaahuatanga katoa

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Hua Zhao, Yulan Cheng, Andrew Kalra, Ke Ma, Yueyuan Zheng, Benjamin Ziman, Caitlin M. Tressler, Kristine Glunde, Eun Ji Shin, Saowanee Ngamruengphong, Mouen A. Khashab, Vikesh K. Singh, Robert A. Anders, Simran Jit, Nicolas Wyhs, Wei Chen, Xu Li, De‐Chen Lin, Stephen J. Meltzer
Hōputu: Artigo
Reo:Ingarihi
I whakaputaina: 2022
Urunga tuihono:https://doi.org/10.1126/scitranslmed.abq6146
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Ipurangi

https://doi.org/10.1126/scitranslmed.abq6146

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