The co-evolution of the genome and epigenome in colorectal cancer

The co-evolution of the genome and epigenome in colorectal cancer

Abstract Colorectal malignancies are a leading cause of cancer-related death 1 and have undergone extensive genomic study 2,3 . However, DNA mutations alone do not fully explain malignant transformation 4–7 . Here we investigate the co-evolution of the genome and epigenome of colorectal tumours at s...

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Main Authors: Timon Heide, Jacob Househam, George D. Cresswell, Inmaculada Spiteri, Claire Lynn, Maximilian Mossner, Christopher Kimberley, Javier Fernández-Mateos, Bingjie Chen, Luís Zapata, Chela James, Iros Barozzi, Ketevan Chkhaidze, Daniel Nichol, Vinaya Gunasri, Alison Berner, Melissa Schmidt, Eszter Lakatos, Ann‐Marie Baker, Helena Costa, Miriam Mitchinson, Rocco Piazza, Marnix Jansen, Giulio Caravagna, Daniele Ramazzotti, Darryl Shibata, John Bridgewater, Manuel Rodriguez‐Justo, Luca Magnani, Trevor A. Graham, Andrea Sottoriva
Formato: Artigo
Idioma:Inglês
Publicado em: 2022
Acesso em linha:https://doi.org/10.1038/s41586-022-05202-1
https://www.nature.com/articles/s41586-022-05202-1.pdf
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https://doi.org/10.1038/s41586-022-05202-1
https://www.nature.com/articles/s41586-022-05202-1.pdf

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