Immune dysfunction signatures predict outcomes and define checkpoint blockade–unresponsive microenvironments in acute myeloid leukemia

Immune dysfunction signatures predict outcomes and define checkpoint blockade–unresponsive microenvironments in acute myeloid leukemia

Background. Immune exhaustion and senescence are dominant dysfunctional states of effector T cells and major hurdles for the success of cancer immunotherapy. In the current study, we characterized how acute myeloid leukemia (AML) promotes the generation of senescent-like CD8+ T cells and whether the...

Повний опис

Збережено в:
Бібліографічні деталі
Автори: Sergio Rutella, Jayakumar Vadakekolathu, Francesco Mazziotta, Stephen Reeder, Tung On Yau, Rupkatha Mukhopadhyay, Benjamin Dickins, Heidi Altmann, Michael Krämer, Hanna A. Knaus, Bruce R. Blazar, Vedran Radojčić, Joshua F. Zeidner, Andrea Arruda, Bofei Wang, Hussein A. Abbas, Mark D. Minden, Sarah K. Tasian, Martin Bornhäuser, Ivana Gojo, Leo Luznik
Формат: Artigo
Мова:Англійська
Опубліковано: 2022
Онлайн доступ:https://doi.org/10.1172/jci159579
http://www.jci.org/articles/view/159579/files/pdf
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Інтернет

https://doi.org/10.1172/jci159579
http://www.jci.org/articles/view/159579/files/pdf

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