Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs

Systemic immunosuppression promotes survival and integration of subretinally implanted human ESC-derived photoreceptor precursors in dogs

Regenerative therapies aimed at replacing photoreceptors are a promising approach for the treatment of otherwise incurable causes of blindness. However, such therapies still face significant hurdles, including the need to improve subretinal delivery and long-term survival rate of transplanted cells,...

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Hlavní autoři: Ana Ripolles‐Garcia, Natalia V. Dolgova, M. Joseph Phillips, Svetlana Savina, Allison L. Ludwig, Sara A. Stuedemann, Uchenna Nlebedum, John H. Wolfe, Oliver A. Garden, Arvydas Maminishkis, Juan Amaral, Kapil Bharti, David M. Gamm, Gustavo D. Aguirre, William A. Beltran
Médium: Artigo
Jazyk:angličtina
Vydáno: 2022
On-line přístup:https://doi.org/10.1016/j.stemcr.2022.06.009
https://www.cell.com/article/S2213671122003253/pdf
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https://doi.org/10.1016/j.stemcr.2022.06.009
https://www.cell.com/article/S2213671122003253/pdf

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