Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer’s disease

Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer’s disease

In Alzheimer's disease (AD), where amyloid-β (Aβ) and tau deposits in the brain, hyperexcitation of neuronal networks is an underlying disease mechanism, but its cause remains unclear. Here, we used the Collaborative Cross (CC) forward genetics mouse platform to identify modifier genes of neuro...

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Bibliografiske detaljer
Main Authors: Yuanyuan Deng, Mian Bi, Fabien Delerue, Shelley L. Forrest, Gabriella Chan, Julia van der Hoven, Annika van Hummel, Astrid Feiten, Seojin Lee, Iván Martínez-Valbuena, Tim Karl, Gábor G. Kovács, Grant Morahan, Yazi D. Ke, Lars M. Ittner
Format: Artigo
Sprog:engelsk
Udgivet: 2022
Online adgang:https://doi.org/10.1007/s00401-022-02457-w
https://link.springer.com/content/pdf/10.1007/s00401-022-02457-w.pdf
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https://doi.org/10.1007/s00401-022-02457-w
https://link.springer.com/content/pdf/10.1007/s00401-022-02457-w.pdf

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