Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer’s disease

Loss of LAMP5 interneurons drives neuronal network dysfunction in Alzheimer’s disease

In Alzheimer's disease (AD), where amyloid-β (Aβ) and tau deposits in the brain, hyperexcitation of neuronal networks is an underlying disease mechanism, but its cause remains unclear. Here, we used the Collaborative Cross (CC) forward genetics mouse platform to identify modifier genes of neuro...

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Autores principales: Yuanyuan Deng, Mian Bi, Fabien Delerue, Shelley L. Forrest, Gabriella Chan, Julia van der Hoven, Annika van Hummel, Astrid Feiten, Seojin Lee, Iván Martínez-Valbuena, Tim Karl, Gábor G. Kovács, Grant Morahan, Yazi D. Ke, Lars M. Ittner
Formato: Artigo
Lenguaje:inglés
Publicado: 2022
Acceso en línea:https://doi.org/10.1007/s00401-022-02457-w
https://link.springer.com/content/pdf/10.1007/s00401-022-02457-w.pdf
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https://doi.org/10.1007/s00401-022-02457-w
https://link.springer.com/content/pdf/10.1007/s00401-022-02457-w.pdf

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