Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors

Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors

Abstract Serine hydroxymethyltransferase (SHMT) produces 5,10-methylenetetrahydrofolate (CH 2 -THF) from tetrahydrofolate with serine to glycine conversion. SHMT is a potential drug target in parasites, viruses and cancer. (+)-SHIN-1 was developed as a human SHMT inhibitor for cancer therapy. Howeve...

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Main Authors: Yuko Makino, Chihiro Oe, Kazuya Iwama, Satoshi Suzuki, Akie Nishiyama, Kazuya Hasegawa, Haruka Okuda, Kazushige Hirata, Mariko Ueno, Kumi Kawaji, Mina Sasano, Emiko Usui, Toshiaki Hosaka, Yukako Yabuki, Mikako Shirouzu, Makoto Katsumi, Kazutaka Murayama, Hironori Hayashi, Eiichi Kodama
Format: Artigo
Language:English
Published: 2022
Online Access:https://doi.org/10.1038/s42003-022-03555-x
https://www.nature.com/articles/s42003-022-03555-x.pdf
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https://doi.org/10.1038/s42003-022-03555-x
https://www.nature.com/articles/s42003-022-03555-x.pdf

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