TAB2 deficiency induces dilated cardiomyopathy by promoting RIPK1-dependent apoptosis and necroptosis
Mutations in TGF-β–activated kinase 1 binding protein 2 (TAB2) have been implicated in the pathogenesis of dilated cardiomyopathy and/or congenital heart disease in humans, but the underlying mechanisms are currently unknown. Here, we identified an indispensable role for TAB2 in regulating myocardia...
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| Autores principales: | , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | inglés |
| Publicado: |
2022
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| Acceso en línea: | https://doi.org/10.1172/jci152297 http://www.jci.org/articles/view/152297/files/pdf |
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