A Systematic Review of the Mechanisms Involved in Immune Checkpoint Inhibitors Cardiotoxicity and Challenges to Improve Clinical Safety

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block CTLA-4, PD-1, or PD-L1 and induce the activation of the immune system against cancer. Despite the efficacy of ICIs, which has improved the oncotherapy for patients with a variety of malignancies, several immune-related adverse...

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Main Authors: Néstor Rubio‐Infante, Yoel A. Ramírez‐Flores, Elena C. Castillo, Omar Lozano, Gerardo García‐Rivas, Guillermo Torre‐Amione
פורמט: Revisão
שפה:אנגלית
יצא לאור: 2022
גישה מקוונת:https://doi.org/10.3389/fcell.2022.851032
https://www.frontiersin.org/articles/10.3389/fcell.2022.851032/pdf
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