Androgen receptor and MYC equilibration centralizes on developmental super-enhancer

Androgen receptor and MYC equilibration centralizes on developmental super-enhancer

Androgen receptor (AR) in prostate cancer (PCa) can drive transcriptional repression of multiple genes including MYC, and supraphysiological androgen is effective in some patients. Here, we show that this repression is independent of AR chromatin binding and driven by coactivator redistribution, and...

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Main Authors: Haiyang Guo, Yiming Wu, Mannan Nouri, Sándor Spisák, Joshua W. Russo, Adam G. Sowalsky, Mark M. Pomerantz, Wei Zhao, Keegan Korthauer, Ji-Heui Seo, Liyang Wang, Seiji Arai, Matthew L. Freedman, Housheng Hansen He, Shaoyong Chen, Steven P. Balk
Format: Artigo
Language:English
Published: 2021
Online Access:https://doi.org/10.1038/s41467-021-27077-y
https://www.nature.com/articles/s41467-021-27077-y.pdf
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https://doi.org/10.1038/s41467-021-27077-y
https://www.nature.com/articles/s41467-021-27077-y.pdf

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