Unraveling the hidden role of a uORF-encoded peptide as a kinase inhibitor of PKCs

Significance Bioinformatic analysis revealed that approximately 40% of human messenger RNAs contain upstream open reading frames (uORFs) in their 5′ untranslated regions. Some of these sequences are translated, but the function of the encoded peptides remains unknown. Our study revealed a uORF encod...

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Main Authors: Divya Ram Jayaram, Sigal A. Frost, Chanan M Argov, Vijayasteltar Belsamma Liju, Nikhil Ponnoor Anto, Amitha Muraleedharan, Assaf Ben-Ari, Rose Sinay, Ilan Smoly, Ofra Novoplansky, Noah Isakov, Debra Toiber, Chen Keasar, Moshe Elkabets, Esti Yeger‐Lotem, Etta Livneh
Formato: Artigo
Idioma:inglés
Publicado: 2021
Acceso en liña:https://doi.org/10.1073/pnas.2018899118
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