Allele-specific variation at<i>APOE</i>increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer’s disease and myocardial infarction

Allele-specific variation at<i>APOE</i>increases nonalcoholic fatty liver disease and obesity but decreases risk of Alzheimer’s disease and myocardial infarction

Abstract Nonalcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is highly correlated with metabolic disease. NAFLD results from environmental exposures acting on a susceptible polygenic background. This study performed the largest multiethnic investigation of exonic...

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Main Authors: Colin N. A. Palmer, Bratati Kahali, Annapurna Kuppa, Yanhua Chen, Xiaomeng Du, Mary F. Feitosa, Lawrence F. Bielak, Jeffrey R. O’Connell, Solomon K. Musani, Xiuqing Guo, Albert V. Smith, Kathleen A. Ryan, Gudny Eirksdottir, Matthew Allison, Donald W. Bowden, Matthew J. Budoff, J. Jeffrey Carr, Yii‐Der I. Chen, Kent D. Taylor, Adolfo Correa, Breland Crudup, Brian Halligan, Jian Yang, Sharon L. R. Kardia, Lenore J. Launer, Yi‐Ping Fu, Thomas H. Mosley, Jill M. Norris, James G. Terry, Christopher J. O’Donnell, Jerome I. Rotter, Lynne E. Wagenknecht, Vilmundur Guðnason, Michael A. Province, Patricia A. Peyser, Elizabeth K. Speliotes
Formato: Artigo
Idioma:inglés
Publicado: 2021
Acceso en liña:https://doi.org/10.1093/hmg/ddab096
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https://doi.org/10.1093/hmg/ddab096

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