Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2

Drug repurposing screens reveal cell-type-specific entry pathways and FDA-approved drugs active against SARS-Cov-2

There is an urgent need for antivirals to treat the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To identify new candidates, we screen a repurposing library of ∼3,000 drugs. Screening in Vero cells finds few antivirals, while screening in human Huh7.5 cells validates 2...

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Detalhes bibliográficos
Main Authors: Mark Dittmar, Jae Seung Lee, Kanupriya Whig, Elisha Segrist, Minghua Li, Brinda Kamalia, Lauren Castellana, Kasirajan Ayyanathan, Fabian L. Cardenas‐Diaz, Edward E. Morrisey, Rachel Truitt, Wenli Yang, Kellie A. Jurado, Kirandeep Samby, Holly Ramage, D. Schultz, Sara Cherry
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Acesso em linha:https://doi.org/10.1016/j.celrep.2021.108959
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https://doi.org/10.1016/j.celrep.2021.108959

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