Cas9-directed immune tolerance in humans—a model to evaluate regulatory T cells in gene therapy?

Abstract The dichotomic nature of the adaptive immune response governs the outcome of clinical gene therapy. On the one hand, neutralizing antibodies and cytotoxic T cells can have a dramatic impact on the efficacy and safety of human gene therapies. On the other hand, regulatory T cells (Treg) can...

Бүрэн тодорхойлолт

-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Dimitrios L. Wagner, Lena Peter, Michael Schmueck‐Henneresse
Формат: Revisão
Хэл сонгох:англи
Хэвлэсэн: 2021
Онлайн хандалт:https://doi.org/10.1038/s41434-021-00232-2
https://www.nature.com/articles/s41434-021-00232-2.pdf
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