Cas9-directed immune tolerance in humans—a model to evaluate regulatory T cells in gene therapy?
Abstract The dichotomic nature of the adaptive immune response governs the outcome of clinical gene therapy. On the one hand, neutralizing antibodies and cytotoxic T cells can have a dramatic impact on the efficacy and safety of human gene therapies. On the other hand, regulatory T cells (Treg) can...
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| Main Authors: | , , |
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| Format: | Revisão |
| Sprog: | engelsk |
| Udgivet: |
2021
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| Online adgang: | https://doi.org/10.1038/s41434-021-00232-2 https://www.nature.com/articles/s41434-021-00232-2.pdf |
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