The human VRK1 chromatin kinase in cancer biology
VRK1 is a nuclear Ser-Thr chromatin kinase that does not mutate in cancer, and is overexpressed in many types of tumors and associated with a poor prognosis. Chromatin VRK1 phosphorylates several transcription factors, including p53, histones and proteins implicated in DNA damage response pathways....
שמור ב:
Main Authors: | Ignacio Campillo‐Marcos, Raúl García-González, Elena Navarro-Carrasco, Pedro A. Lazo |
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פורמט: | Revisão |
שפה: | אנגלית |
יצא לאור: |
2021
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גישה מקוונת: | https://doi.org/10.1016/j.canlet.2020.12.032 |
תגים: |
הוספת תג
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פריטים דומים
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Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?
מאת: Campillo-Marcos, Ignacio, et al.
יצא לאור: (2018) -
Implication of the VRK1 chromatin kinase in the signaling responses to DNA damage: a therapeutic target?
מאת: Ignacio Campillo‐Marcos, et al.
יצא לאור: (2018) -
Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase
מאת: Campillo-Marcos, Ignacio, et al.
יצא לאור: (2019) -
Olaparib and ionizing radiation trigger a cooperative DNA-damage repair response that is impaired by depletion of the VRK1 chromatin kinase
מאת: Ignacio Campillo‐Marcos, et al.
יצא לאור: (2019) -
Differential Inhibitor Sensitivity between Human Kinases VRK1 and VRK2
מאת: Vázquez-Cedeira, Marta, et al.
יצא לאור: (2011)