Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2
Increased activity of the lysine methyltransferase NSD2 driven by translocation and activating mutations is associated with multiple myeloma and acute lymphoblastic leukemia, but no NSD2-targeting chemical probe has been reported to date. Here, we present the first antagonists that block the protein...
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| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | inglés |
| Publicado: |
2021
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| Acceso en línea: | https://doi.org/10.1021/acs.jmedchem.0c01768 |
| Etiquetas: |
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