Whole-genome characterization of lung adenocarcinomas lacking alterations in the RTK/RAS/RAF pathway

Whole-genome characterization of lung adenocarcinomas lacking alterations in the RTK/RAS/RAF pathway

RTK/RAS/RAF pathway alterations (RPAs) are a hallmark of lung adenocarcinoma (LUAD). In this study, we use whole-genome sequencing (WGS) of 85 cases found to be RPA(-) by previous studies from The Cancer Genome Atlas (TCGA) to characterize the minority of LUADs lacking apparent alterations in this p...

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Main Authors: Jian Carrot‐Zhang, Xiaotong Yao, Siddhartha Devarakonda, Aditya Deshpande, Jeffrey S. Damrauer, Tiago C. Silva, Christopher K. Wong, Hyo Young Choi, Ina Felau, A. Gordon Robertson, Mauro A. A. Castro, Lisui Bao, Esther Rheinbay, Eric Minwei Liu, Tuan Trieu, David Haan, Christina Yau, Toshinori Hinoue, Yuexin Liu, Ofer Shapira, Kiran Kumar, Karen Mungall, Hailei Zhang, Jake June-Koo Lee, Ashton C. Berger, Galen F. Gao, Binyamin Zhitomirsky, Wen-Wei Liang, Meng Zhou, Sitapriya Moorthi, Alice H. Berger, Jun Li, Michael C. Zody, Li Ding, Andrew D. Cherniack, Gad Getz, Olivier Elemento, Christopher C. Benz, Joshua M. Stuart, Jean C. Zenklusen, Rameen Beroukhim, Jason C. Chang, Joshua D. Campbell, D. Neil Hayes, Lixing Yang, Peter W. Laird, John N. Weinstein, David J. Kwiatkowski, Ming‐Sound Tsao, William D. Travis, Ekta Khurana, Benjamin P. Berman, Katherine A. Hoadley, Nicolas Robine, Matthew Meyerson, Ramaswamy Govindan, Marcin Imieliński, Kanika Arora, Minita Shah, Jennifer M. G. Shelton, Reanne Bowlby, Verena Friedl, Mary J. Goldman, Brian Craft, David I. Heiman, Iman Hajirasouliha, Camir Ricketts, Pavana Anur, Kami Chiotti, Rory Johnson, John A. Demchok, Martin L. Ferguson, Anab Kemal, Roy Tarnuzzer, Linghua Wang, Liming Yang, Paul T. Spellman, Benjamin J. Raphael, Rehan Akbani, Jingchun Zhu, Steven J.M. Jones, Hui Shen
Format: Artigo
Language:English
Published: 2021
Online Access:https://doi.org/10.1016/j.celrep.2021.108707
https://www.cell.com/article/S2211124721000206/pdf
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https://doi.org/10.1016/j.celrep.2021.108707
https://www.cell.com/article/S2211124721000206/pdf

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