Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon

Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon

BackgroundThe mechanisms underlying altered susceptibility and propensity to severe Coronavirus disease 2019 (COVID-19) disease in at-risk groups such as patients with chronic obstructive pulmonary disease (COPD) are poorly understood. Inhaled corticosteroids (ICSs) are widely used in COPD, but the...

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Detalhes bibliográficos
Principais autores: Lydia J. Finney, Nicholas Glanville, Hugo Farne, Julia Aniscenko, Peter Fenwick, Samuel V. Kemp, Maria-Belen Trujillo-Torralbo, Su-Ling Loo, Maria Adelaide Calderazzo, Jadwiga A. Wedzicha, Patrick Mallia, Nathan W. Bartlett, Sebastian L. Johnston, Aran Singanayagam
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Acesso em linha:https://doi.org/10.1016/j.jaci.2020.09.034
http://www.jacionline.org/article/S009167492031407X/pdf
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https://doi.org/10.1016/j.jaci.2020.09.034
http://www.jacionline.org/article/S009167492031407X/pdf

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