Resolution of R-loops by INO80 promotes DNA replication and maintains cancer cell proliferation and viability
Abstract Collisions between the DNA replication machinery and co-transcriptional R-loops can impede DNA synthesis and are a major source of genomic instability in cancer cells. How cancer cells deal with R-loops to proliferate is poorly understood. Here we show that the ATP-dependent chromatin remod...
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| Główni autorzy: | , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | angielski |
| Wydane: |
2020
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| Dostęp online: | https://doi.org/10.1038/s41467-020-18306-x https://www.nature.com/articles/s41467-020-18306-x.pdf |
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