p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo

Significance Although p53 is highly studied, the molecular and physiological consequences of the p53 transcriptional response are poorly understood. Through RNA sequencing of multiple mouse tissues upon genetic activation of p53, we identified hundreds of tissue-specific p53 target genes and a set o...

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Hlavní autoři: Sydney M. Moyer, Amanda R. Wasylishen, Yuan Qi, Natalie W. Fowlkes, Xiaoping Su, Guillermina Lozano
Médium: Artigo
Jazyk:angličtina
Vydáno: 2020
On-line přístup:https://doi.org/10.1073/pnas.2008474117
https://www.pnas.org/content/pnas/117/38/23663.full.pdf
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