Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation

Cotargeting of Mitochondrial Complex I and Bcl-2 Shows Antileukemic Activity against Acute Myeloid Leukemia Cells Reliant on Oxidative Phosphorylation

Targeting oxidative phosphorylation (OXPHOS) is a promising strategy to improve treatment outcomes of acute myeloid leukemia (AML) patients. IACS-010759 is a mitochondrial complex I inhibitor that has demonstrated preclinical antileukemic activity and is being tested in Phase I clinical trials. Howe...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Fangbing Liu, Hasini A. Kalpage, Deying Wang, Holly Edwards, Maik Hüttemann, Jun Ma, Yongwei Su, Jenna L. Carter, Xinyu Li, Lisa Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Guan Wang, Jeffrey W. Taub, Yubin Ge
Fformat: Artigo
Iaith:Saesneg
Cyhoeddwyd: 2020
Mynediad Ar-lein:https://doi.org/10.3390/cancers12092400
https://www.mdpi.com/2072-6694/12/9/2400/pdf?version=1598276385
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https://doi.org/10.3390/cancers12092400
https://www.mdpi.com/2072-6694/12/9/2400/pdf?version=1598276385

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