Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from <i>Mycobacterium tuberculosis</i>

Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from <i>Mycobacterium tuberculosis</i>

Dihydrofolate reductase (DHFR), a key enzyme involved in folate metabolism, is a widely explored target in the treatment of cancer, immune diseases, bacteria, and protozoa infections. Although several antifolates have proved successful in the treatment of infectious diseases, they have been underexp...

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Bibliografiske detaljer
Main Authors: João Augusto Ribeiro, Alexander Hammer, Gerardo Andrés Libreros-Zúñiga, S.M. Chavez-Pacheco, Petros A. Tyrakis, Gabriel S. de Oliveira, Timothy Kirkman, Jamal El Bakali, Silvana A. Rocco, Maurício L. Sforça, Roberto Parise‐Filho, Anthony G. Coyne, Tom L. Blundell, Chris Abell, M.V.B. Dias
Format: Artigo
Sprog:engelsk
Udgivet: 2020
Online adgang:https://doi.org/10.1021/acsinfecdis.0c00263
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https://doi.org/10.1021/acsinfecdis.0c00263

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