Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from <i>Mycobacterium tuberculosis</i>

Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase from <i>Mycobacterium tuberculosis</i>

Dihydrofolate reductase (DHFR), a key enzyme involved in folate metabolism, is a widely explored target in the treatment of cancer, immune diseases, bacteria, and protozoa infections. Although several antifolates have proved successful in the treatment of infectious diseases, they have been underexp...

全面介紹

Saved in:
書目詳細資料
Main Authors: João Augusto Ribeiro, Alexander Hammer, Gerardo Andrés Libreros-Zúñiga, S.M. Chavez-Pacheco, Petros A. Tyrakis, Gabriel S. de Oliveira, Timothy Kirkman, Jamal El Bakali, Silvana A. Rocco, Maurício L. Sforça, Roberto Parise‐Filho, Anthony G. Coyne, Tom L. Blundell, Chris Abell, M.V.B. Dias
格式: Artigo
語言:英语
出版: 2020
在線閱讀:https://doi.org/10.1021/acsinfecdis.0c00263
標簽: 添加標簽
沒有標簽, 成為第一個標記此記錄!

因特網

https://doi.org/10.1021/acsinfecdis.0c00263

相似書籍