High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow

High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow

Obesity is linked to increased risk for and severity of Alzheimer's disease (AD). Cerebral blood flow (CBF) reductions are an early feature of AD and are also linked to obesity. We recently showed that non-flowing capillaries, caused by adhered neutrophils, contribute to CBF reduction in mouse...

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Những tác giả chính: Oliver Bracko, Lou Vinarcsik, Jean C. Cruz Hernández, Nancy E. Ruiz‐Uribe, Mohammad Haft‐Javaherian, Kaja Falkenhain, Egle M. Ramanauskaite, Muhammad Ali, Aditi Mohapatra, Madisen A. Swallow, Brendah N. Njiru, Victorine Muse, Pietro Michelucci, Nozomi Nishimura, Chris B. Schaffer
Định dạng: Artigo
Ngôn ngữ:Tiếng Anh
Được phát hành: 2020
Truy cập trực tuyến:https://doi.org/10.1038/s41598-020-65908-y
https://www.nature.com/articles/s41598-020-65908-y.pdf
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https://doi.org/10.1038/s41598-020-65908-y
https://www.nature.com/articles/s41598-020-65908-y.pdf

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